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The STEM-PD Clinical Trial

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  • Why Parkinson’s disease?
  • What is the STEM-PD product?
    • What are the STEM-PD cells?
    • What are pluripotent stem cells?
    • How can pluripotent stem cells be used to make dopamine neurons?
    • How do we know that the STEM-PD cells are safe and effective?
  • What is the STEM-PD Trial?
  • The STEM-PD Team
  • Publications
  • News

STEM-PD is a clinical trial run by clinical and preclinical research teams in Sweden and the UK. The goal of the trial is to develop a safe and efficacious stem cell-based treatment for Parkinson’s disease.

The trial involves transplantation of stem cell-derived dopamine STEM-PD cells into the brains of Parkinson’s disease patients. The stem cell product to be transplanted in this trial is named “STEM-PD”. The cells are designed to form new functional dopamine neurons in the brain of the patient after transplantation, with the aim of replacing those neurons which have been lost during the course of the disease.

This clinical trial is an investigator-lead clinical trial sponsored by Skåne University Hospital in Lund and registered as EudraCT 2021-001366-38. The development of the product and the clinical trial has been funded by national and EU funding agencies as well as by the pharmaceutical company Novo Nordisk.

Why develop a stem cell therapy for Parkinson’s disease?

Parkinson’s disease (PD) is a progressive neurodegenerative condition that is classically characterised by slowness of movement, unstable gait, stiff muscles, and tremor. These motor symptoms are caused by the loss of a specific type of neurons which produce and release a chemical called dopamine. As the dopamine-producing neurons are progressively lost, the motor symptoms of…

Read more Why develop a stem cell therapy for Parkinson’s disease?

What is in the STEM-PD product and how does it work?

The STEM-PD product is a solution of dopamine progenitor cells, which means that they are immature cells which can form functional dopamine neurons upon maturation in the brain. To obtain maximal clinical benefit, the cells are implanted into the area of the brain where dopamine normally exerts its effects on motor functions, which is a…

Read more What is in the STEM-PD product and how does it work?

What are the STEM-PD cells?

The STEM-PD cells are dopamine progenitor cells which are derived from a special type of stem cells called pluripotent stem cells. As the original pluripotent stem cells can divide and multiply, they can generate a large number of dopamine progenitors which can be stored (cryo-preserved) for a long time, thus making it possible to do extensive…

Read more What are the STEM-PD cells?

The experience of the STEM-PD Trial team
CONTACT INFORMATION

Contact us on:
info@stem-pd.org

TRIAL REGISTRIES  
ClinicalTrials.gov
Human Pluripotent Stem Cell Registry

  • Home
  • Why Parkinson’s disease?
  • What is the STEM-PD product?
    • What are the STEM-PD cells?
    • What are pluripotent stem cells?
    • How can pluripotent stem cells be used to make dopamine neurons?
    • How do we know that the STEM-PD cells are safe and effective?
  • What is the STEM-PD Trial?
  • The STEM-PD Team
  • Publications
  • News
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