A team led by Associate Professor Agnete Kirkeby has published a review in Cell Stem Cell summarizing clinical trials using human pluripotent stem cells (hPSCs), which can self-renew and transform into any human cell type. Over 1,200 patients across 116 trials have received these treatments, targeting conditions like Parkinson’s, blindness, diabetes, and cancer. The review provides the first comprehensive data on patient numbers, cell doses, and immunosuppression strategies, essential for ensuring the safety of such therapies. No major safety concerns, like tumour formation, have been reported. This work is expected to be a valuable resource for advancing stem cell research worldwide.
Read the full review here: Cell Stem Cell. 2025 Jan 2;32(1):10-37. doi: 10.1016/j.stem.2024.12.005.
The STEM-PD Clinical Trial 